Fig. 3.

Dissection and clustering of mature myeloid lineages in AML patients and healthy donors. a UMAP plot of Monocyte/Macrophages from Fig. 1a-represented Mono/Mac cluster. These mature myeloid cells can be divided into 9 subsets without CD14⁺CD3D⁺ subset. b Dot plot of differentially key cell-type marker genes. c Heatmap of mean expression of selected cytokine genes in each cell subset. d Proportion of 9 mature myeloid subsets in myeloid population subsets in each AML patient or healthy donor. Only samples of containing ≥20 myeloid cells were represented. e The Kaplan-Meier overall survival curves of TCGA AML patients grouped by specific MACRO⁺ subset gene sets and myeloid-related genes (CD163, ITGAM, MMP9, and CCL5). + represents censored observations, and P value was calculated by multivariate Cox regression