Table 2.
Summarization of major immune cell subset in AML BM microenvironment and prognosis
| Cluster | Subset | Representative prognostic genes | Prognosis |
|---|---|---|---|
| Mast cell | – | Mast cell-gene signature (215 genes) | Good |
| DC | CD206+ DC subset | CD206+ DC-gene signature (111 genes), MRC1, TNFSF8 | Poor |
| – | CX3CR1, TGFB1, CLEC7A, ITGAX, ITGB2 | Poor | |
| Mono/Mac | MARCOhigh subset | MARCOhigh subset-gene signature (203 genes) | Poor |
| – | CCL22, CD163, ITGAM, CCL5 | Poor | |
| – | MMP9 | Good | |
| T | Treg | Treg subset-gene signature (173 genes) | Poor |
| Dysfunctional/exhausted T | Dysfunctional/exhausted-gene set (LAG3, TIGIT, CTLA4, HAVCR2, TOX, PDCD1, CD274, PDCD1LG2) | Poor | |
| – | CD274, PDCD1LG2, PDCD1, BATF | Poor |