Table 1.
Baseline characteristics.
| Characteristic | TRD Patients (n = 129) | Control Participants (n = 28) | |
|---|---|---|---|
| Gender | Female: n (%) | 77 (60%) | 16 (57%) |
| Male: n (%) | 52 (40%) | 12 (43%) | |
| Age | Mean (SD) | 47.20 | 43.8 (9.1) |
| BMI | Mean (SD) | 30.88 (6.34) | 25.4 (5.2) |
| CTQ score a | Mean (SD) | 52.05 (21.21) | 34.2 (10.2) |
| MADRS score | Mean (SD) | 28.09 (6.12) | n/a |
| IL-6 (log-pg/mL) a | Mean (SD) | −0.077 (0.282) | −0.350 (0.298) |
| TNFα (log-pg/mL) a | Mean (SD) | 0.347 (0.142) | 0.233 (0.120) |
| CRP (log-ug/mL) a | Mean (SD) | 6.491 (0.512) | 5.908 (0.537) |
| IL-10 (log-pg/mL) a | Mean (SD) | −0.437 (0.285) | −0.545 (0.202) |
Characteristics of the sample at baseline: gender, age, BMI and IL-10 level did not differ between TRD and control participants. TRD participants randomised to metyrapone did not differ from those randomised to placebo on any baseline characteristics. a Childhood trauma severity, IL-6, TNF and CRP were higher in TRD than control participants. Log transformed values of inflammatory proteins presented. Abbreviations: TRD = treatment-resistant depression, BMI = body mass index, CTQ = childhood trauma questionnaire, MADRS = Montgomery–Åsberg Depression Rating Scale, IL-6 = interleukin 6, TNFα = tumour necrosis factor, CRP = c-reactive protein, IL-10 = interleukin 10.