Table 2.
Symptoms and inflammation throughout the trial in metyrapone and placebo groups.
| Characteristic | TRD Patients | Metyrapone | Placebo | |
|---|---|---|---|---|
| MADRS | Week 0 | 28.09 (6.12) |
27.76 (6.98)
Adherent: 27.30 (6.72) Not adherent: 28.57 (7.48) |
28.39 (5.20) |
| Week 5 | 22.24 (11.00) |
27.72 (11.68)
Adherent: 20.55 (10.58) Not adherent: 28.93 (12.81) |
21.80 (10.43) | |
| IL-6 (log-pg/mL) | Week 0 | −0.077 (0.282) |
−0.0511 (0.273)
Adherent: −0.057 (0.301) Not adherent: −0.04 (0.222) |
−0.102 (0.290) |
| Week 5 | −0.049 (0.331) |
0.017 (0.288)
Adherent: 0.087 (0.261) Not adherent: −0.148 (0.287) |
−0.113 (0.358) | |
| TNFα (log-pg/mL) | Week 0 | 0.347 (0.142) |
0.368 (0.143)
Adherent: 0.365 (0.142) Not adherent: 0.374 (0.149) |
0.328 (0.139) |
| Week 5 | 0.344 (0.228) |
0.352 (0.223)
Adherent: 0.375 (0.183) Not adherent: 0.298 (0.298) |
0.337 (0.233) | |
| CRP (log-ug/mL) | Week 0 | 6.491 (0.512) |
6.485 (0.551)
Adherent: 6.427 (0.562) Not adherent: 6.585 (0.528) |
6.496 (0.475) |
| Week 5 | 6.465 (0.567) |
6.501 (0.549)
Adherent: 6.428 (0.484) Not adherent: 6.672 (0.661) |
6.431 (0.586) | |
| IL-10 (log-pg/mL) | Week 0 | −0.437 (0.285) |
−0.452 (0.298)
Adherent: −0.417 (0.284) Not adherent: −0.514 (0.318) |
−0.422 (0.273) |
| Week 5 | −0.393 (0.345) |
−0.379 (0.351)
Adherent: −0.322 (0.357) Not adherent: −0.511 (0.308) |
−0.407 (0.341) |
The italics indicate that the metyrapone and placebo columns are subsets of the full ‘trd patients’ sample. Characteristics of patients randomised to metyrapone versus placebo before and after treatment. Placebo n = 66, metyrapone n = 63 (adherent n = 40, non-adherent n = 23). For more details regarding missing data, see Table S1. IL-6 was higher in metyrapone participants (as a whole, randomised group and in the adherent group) at week 5 compared to week 0, and at week 5 compared to placebo-randomised participants. Log transformed values of inflammatory proteins presented. Abbreviations: TRD = treatment-resistant depression, MADRS = Montgomery–Åsberg Depression Rating Scale, IL-6 = interleukin 6, TNFα = tumour necrosis factor, CRP = c-reactive protein, IL-10 = interleukin 10.