Table 3.
Predictive effects of inflammatory proteins on subsequent outcome to metyrapone versus placebo.
| Protein | Analysis | Inflammatory Protein Predictor Effect a | Interaction Effect (Protein x Group) b | ||||
|---|---|---|---|---|---|---|---|
| Coefficient (95% CI) | SES | p Value | Coefficient (95% CI) | SES | p Value | ||
| IL-6 | Per-protocol (n = 106) | 2.57 (−0.67, 5.96) | 0.17 | 0.125 | −3.58 (−9.61, 3.50) | −0.15 | 0.280 |
| mITT (n = 129) | 3.31 (0.24, 6.46) | 0.20 | 0.034 * | −2.00 (−7.74, 5.00) | −0.08 | 0.532 | |
| TNFα | Per-protocol (n = 106) | 2.56 (−2.74, 7.87) | 0.08 | 0.347 | 8.17 (−1.48, 19.70) | 0.36 | 0.127 |
| mITT (n = 129) | 2.56 (−2.74, 7.87) | 0.08 | 0.347 | 8.24 (−1.59, 18.01) | 0.36 | 0.097 | |
| CRP | Per-protocol (n = 106) | 0.67 (−0.84, 2.61) | 0.08 | 0.437 | 0.50 (−3.10, 4.04) | 0.35 | 0.782 |
| mITT (n = 129) | 1.14 (−0.32, 2.94) | 0.12 | 0.176 | 1.16 (−2.09, 4.78) | 0.80 | 0.508 | |
| IL-10 | Per-protocol (n = 106) | −0.19 (−3.65, 3.26) | −0.01 | 0.914 | −0.56 (−7.69, 6.73) | −0.10 | 0.880 |
| mITT (n = 129) | −0.19 (−3.65, 3.26) | −0.01 | 0.914 | 1.08 (−6.05, 8.45) | 0.18 | 0.767 | |
a linear regression including baseline protein (independent variable), treatment group and baseline depression severity (MADRS score) (covariate) on depression outcome at week 5 (dependent variable). b regression including baseline protein, baseline depression severity, treatment group and protein x group interaction effect as potential moderator of week 5 depression outcome (dependent variable). * statistically significant at p 0.05. Abbreviations: SES = standardised effect size, mITT = modified intention to treat analysis, IL-6 = interleukin 6, TNFα = tumour necrosis factor, CRP = c-reactive protein, IL-10 = interleukin 10.