Table 1.

Genes/proteins of interest that are expressed in LK neurons in Drosophila.

Cell Type	Co-Expression	Stage	Function	References
LHLK	Translin	Adult	Starvation-induced sleep suppression	[111]
LHLK	Dimmed	Larva, adult	Neuron size, LK production	[106]
LHLK	AMPK 1	Adult	Increases LHLK activity in fed flies	[48]
SELK	dInR	Adult	Not tested	[96]
ALK/ITPn	ITP, sNPF, TK	Larva 2, adult	Stress responses, water and ion homeostasis, drinking and feeding3	[43,45]
ALK/ITPn	LKR	Adult	Not tested	[38]
ALK/ITPn	ImpL2 4	Adult	Promotes insulin signaling and uptake	[98]
ALK/ITPn	dInR	Adult	Activates insulin signaling	[98]
ALK/ITPn	dARC1 5		Starvation resistance, starvation-induced hyperactivity	[97]
ALK/ITPn	Minibrain	Adult	Regulates food intake and sNPF expression	[99]
ALK/ITPn	sNPFR1	Adult	Regulates food intake	[99]
ALK/ITPn	Dimmed	Adult	Neuron size	[106]
ABLK	DH44	Larva, adult	Water and ion homeostasis 2	[37]
ABLK	5HT1B-R 6	Adult	Modulates desiccation response	[100]
ABLK	5HT1B-R 6	Larva	Larval locomotion	[42]
ABLK	dInR	Larva, adult	Neuron size, LK production	[96,100]
ABLK	LKR	Larva 7	Not tested	[38]
ABLK	Dimmed	Larva, adult	Neuron size, LK production	[106]
ABLK	ETH-R 7	Larva	Pre-ecdysis behavior	[40]
ABLK	ETH-R	Larva	Tracheal clearance	[41]

Notes: ¹ AMPK, 5′ adenosine monophosphate-activated protein kinase. ² TK not in larval ALK/ITPn. ³ Only tested in adults. ⁴ ImpL2, Imaginal morphogenesis protein-Late 2 (Ecdysone-inducible gene L2). ⁵ dARC1, activity-regulated cytoskeleton-associated protein (ARC)—also expressed in IPCs and AKH cells (APCs). Similar to ImpL2. ⁶ 5HT1B-R, serotonin receptor 1B. ⁷ Only the larva was analyzed, and only one pair of ABLKs express dInR (Figure 5A–C). ⁸ ETH-R, Ecdysis-triggering hormone receptor.