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. 2021 Feb 16;10(2):298. doi: 10.3390/antiox10020298

Figure 2.

Figure 2

Regulatory effects of DK and ECE on the destruction of gut barrier integrity and SGK1 level in the intestine of SHRs. (A,B) The ZO-1 expression level in intestinal tissues was decreased following SHR/water and increased following ECE or DK treatment. (C,D) The number of goblet cells in intestinal tissues was decreased following SHR/water and increased following ECE or DK treatment. (E–G) The tunica muscularis thickness and villi length in intestinal tissue were measured by H&E staining. (H) In intestinal tissues, SGK1 mRNA levels were increased following SHR/water. The addition of ECE and DK decreased the SGK1 mRNA level. For each of the 6 groups, n = 5. Scale bar = 100 µm. **, p < 0.01 and ***, p < 0.001, vs. WKY/water; $, p < 0.05 and $$, p < 0.01, vs. SHR/water; #, p < 0.05 and ##, p < 0.01, vs. SHR/ECE150 (Mann–Whitney U test). DK, dieckol; ECE, Ecklonia cava extract; HE, hematoxylin and eosin staining; PAS, periodic acid–Schiff; SGK1, serine/threonine-protein kinase; SHR, spontaneously hypertensive rat; WKY, Wistar Kyoto rat; ZO-1, zonula occludens-1.