Table 2.
Association results of p.R642G SLC12A3 with biochemical and clinical features
| Trait | CC Genotype (Noncarriers) | CG Genotype (pR642G Heterozygotes) | Effect size (β) | P-value | ||
|---|---|---|---|---|---|---|
| Number | Mean±SEM | Number | Mean±SEM | |||
| Potassium (mmol/L) | 5663 | 4.20±0.004 | 147 | 4.05±0.02 | −0.15 | 2.39×10−9 |
| Cl (mmol/L) | 5663 | 103.48±0.03 | 147 | 103.02±0.18 | −0.66 | 7.93×10−4 |
| BUN (mg/dl) | 5663 | 15.11±0.06 | 147 | 13.84±0.34 | −1.16 | 9.99×10−4 |
| Bicarbonate (mmol/L) | 5473 | 24.35±0.03 | 137 | 24.88±0.20 | 0.56 | 1.09×10−2 |
| Na (mmol/L) | 5662 | 138.46±0.03 | 147 | 138.76±0.17 | 0.15 | 0.39 |
| Creatinine | 5681 | 0.77±0.002 | 147 | 0.76±0.012 | −0.0046 | 0.73 |
| eGFR (ml/min per 1.73 m2) | 5473 | 106.35±0.32 | 137 | 104.61±1.98 | −1.05 | 0.60 |
| Calcium (mg/dl) | 5676 | 9.32±0.005 | 147 | 9.34±0.029 | 0.030 | 0.36 |
| Glucose (mg/dl) | 5495 | 86.09±0.21 | 146 | 84.55±0.74 | −2.18 | 0.11 |
| SBP (mm Hg) | 5904 | 115.31±0.21 | 153 | 116.14±1.29 | −0.54 | 0.67 |
| DBP (mm Hg) | 5904 | 71.11±0.13 | 153 | 71.98±0.77 | −0.27 | 0.74 |
| Heart rate (beats/min) | 5407 | 64.94±0.13 | 137 | 65.45±0.97 | 0.78 | 0.39 |
| Height (m) | 5916 | 166.54±0.12 | 153 | 166.46±0.74 | 0.80 | 0.17 |
| Weight (kg) | 5913 | 73.87±0.19 | 153 | 73.96±1.14 | 1.38 | 0.28 |
| Waist circumference (cm) | 5644 | 88.68±0.16 | 143 | 88.13±0.95 | −0.24 | 0.81 |
| Hip circumference (cm) | 5639 | 102.27±0.14 | 143 | 103.55±0.90 | 1.19 | 0.20 |
| Bone fracture history (%) | 4856 | 6.75±0.36 | 124 | 12.9±3.02 | 0.062 | 9.89×10−3 |
SBP, systolic BP; DBP, diastolic BP.