Table 1.
Overall characteristics of the study cohorts by various CKD-EPI estimating equations and by race
| Characteristic | ||||
|---|---|---|---|---|
| Cohort using eGFRcr as inclusion criteria | ||||
| Overall, n=444 | White, n=157 | Black, n=287 | P value | |
| Median age (IQR) yrs | 62 (55–68) | 63 (56–68) | 62 (54–68) | 0.15 |
| Female, n (%) | 211 (48) | 63 (40) | 148 (52) | 0.02 |
| Median eGFR by CKD-EPI (IQR) in ml/min per 1.73 m2 | 16.6 (13.9–18.4) | 17.6 (15.4–18.8) | 15.8 (13.4–17.9) | <0.001 |
| Median urine protein/creatinine ratio (g/g) (IQR) | 1.29 (0.42–3.02) | 1.11 (0.27–2.25) | 1.36 (0.50–3.36) | 0.03 |
| Diabetes, n (%) | 268 (60.4) | 84 (53.5) | 184 (64.1) | 0.03 |
| Heart failure, n (%) | 71 (16) | 14 (8.9) | 57 (19.9) | 0.003 |
| MI, n (%) | 121 (27.3) | 41 (26.1) | 80 (27.9) | 0.74 |
| PVD, n (%) | 48 (10.8) | 15 (9.6) | 33 (11.5) | 0.63 |
| ESKD, n (%) | 313 (71) | 96 (61) | 217 (76) | 0.002 |
| Death, n (%) | 34 (7.7) | 11 (7.0) | 23 (8.0) | 0.85 |
| Cohort using eGFRcys as inclusion criteria | ||||
| Overall, n=435 | White, n=169 | Black, n=266 | P value | |
| Median age (IQR) yrs | 63 (56–68) | 64 (58–70) | 62 (56–68) | 0.06 |
| Female, n (%) | 219 (50) | 73 (43) | 146 (55) | 0.02 |
| Median eGFR by CKD-EPI (IQR) in ml/min per 1.73 m2 | 16.8 (15.0–18.4) | 17.4 (15.1–18.6) | 16.6 (14.6–18.3) | 0.04 |
| Median urine protein/creatinine ratio (g/g) (IQR) | 1.08 (0.36–2.52) | 0.84 (0.26–2.19) | 1.17 (0.42–2.71) | 0.06 |
| Diabetes, n (%) | 284 (65.3) | 106 (62.7) | 178 (66.9) | 0.41 |
| Heart failure, n (%) | 93 (21.4) | 25 (14.8) | 68 (25.6) | 0.008 |
| MI, n (%) | 147 (33.8) | 62 (36.7) | 85 (32) | 0.35 |
| PVD, n (%) | 57 (13.1) | 25 (14.8) | 32 (12) | 0.47 |
| ESKD, n (%) | 291 (67) | 102 (60) | 189 (71) | 0.02 |
| Death, n (%) | 60 (14) | 26 (15) | 34 (13) | 0.48 |
| Cohort using eGFRcr-cys as inclusion criteria | ||||
| Overall, n=461 | White, n=177 | Black, n=284 | P value | |
| Median age (IQR) yrs | 62 (55–68) | 64 (55–69) | 62 (54–68) | 0.15 |
| Female, n (%) | 229 (49.7) | 76 (42.9) | 153 (53.9) | 0.03 |
| Median eGFR by CKD-EPI (IQR) in ml/min per 1.73 m2 | 17 (14.6–18.5) | 17.4 (15.4–18.5) | 16.5 (14.0–18.4) | 0.01 |
| Median urine protein/creatinine ratio (g/g) (IQR) | 1.15 (0.37–2.59) | 0.90 (0.27–2.18) | 1.33 (0.45–2.89) | 0.009 |
| Diabetes, n (%) | 291 (63.1) | 105 (59.3) | 186 (65.5) | 0.20 |
| Heart failure, n (%) | 83 (18) | 23 (13) | 60 (21.1) | 0.03 |
| MI, n (%) | 136 (29.5) | 54 (30.5) | 82 (28.9) | 0.75 |
| PVD, n (%) | 53 (11.5) | 24 (13.6) | 29 (10.2) | 0.30 |
| ESKD, n (%) | 323 (70.1) | 111 (62.7) | 212 (74.7) | 0.009 |
| Death, n (%) | 47 (10.2) | 20 (11.3) | 27 (9.5) | 0.53 |
MI, myocardial infarction; PVD, peripheral vascular disease.