Table 2.
Time to ESKD starting from eGFR of 20 ml/min per 1.73 m2 by Weibull accelerated failure and Cox models
| Entry into Cohort when eGFR is ≤20 ml/min per 1.73 m2 | Entry into Cohort when eGFR is ≤20 ml/min per 1.73 m2 with Application of an Adjustment Factor to eGFRs for Blacksa | |||
|---|---|---|---|---|
| Blacks Compared with Whites | Weibull Model Time Ratio (95% CI) | Cox model Hazard Ratio (95% CI) | Weibull Model Time Ratio (95% CI) | Cox model Hazard Ratio (95% CI) |
| Univariable model | ||||
| eGFRcr | 0.68 (0.53 to 0.87) | 1.44 (1.13 to 1.84) | 1.00 (0.79 to 1.27) | 1.00 (0.79 to 1.26) |
| eGFRcys | 0.65 (0.49 to 0.84) | 1.46 (1.15 to 1.86) | 1.00 (0.79 to 1.27) | 1.00 (0.80 to 1.25) |
| eGFRcr-cys | 0.69 (0.54 to 0.87) | 1.41 (1.12 to 1.78) | 1.00 (0.80 to 1.25) | 1.00 (0.81 to 1.25) |
| Multivariable model 1b | ||||
| eGFRcr | 0.70 (0.55 to 0.90) | 1.41 (1.10 to 1.80) | 1.05 (0.83 to 1.34) | 0.95 (0.75 to 1.20) |
| eGFRcys | 0.67 (0.51 to 0.88) | 1.42 (1.11 to 1.81) | 1.04 (0.82 to 1.31) | 0.97 (0.77 to 1.22) |
| eGFRcr-cys | 0.69 (0.54 to 0.88) | 1.41 (1.12 to 1.78) | 1.00 (0.80 to 1.25) | 1.00 (0.81 to 1.25) |
a
eGFR of Black individuals was computed by standard CKD-EPI estimating equations and subsequently multiplied by an adjustment factor that we searched for to equalize time spent in the zone of eligibility by race; thus, Blacks would be eligible for entry into the cohort earlier than under current national waitlisting policy.
b
Includes age at entry and sex as covariates.