Table 4.
Overall characteristics of the study cohorts by various CKD-EPI estimating equations and by race, allowing Black patients to enter at higher levels of eGFR on the basis of applied adjustments
| Characteristic | ||||
|---|---|---|---|---|
| Cohort using eGFRcr as inclusion criteria | ||||
| Overall, n=562 | White, n=157 | Black, n=405 | P value | |
| Median age (IQR) yrs | 62 (55–68) | 63 (56–68) | 62 (54–68) | 0.11 |
| Female, n (%) | 270 (48.0) | 63 (40.1) | 207 (51.1) | 0.02 |
| Median eGFRa by CKD-EPI (IQR) in ml/min per 1.73 m2 | 16.4 (13.5–18.4) | 17.6 (15.4–18.8) | 15.9 (12.9–18.0) | <0.001 |
| Median urine protein/creatinine ratio (g/g) (IQR) | 1.11 (0.35–2.71) | 1.11 (0.27–2.25) | 1.12 (0.36–2.78) | 0.46 |
| Diabetes, n (%) | 341 (60.7) | 84 (53.5) | 257 (63.5) | 0.03 |
| Heart failure, n (%) | 91 (16.2) | 14 (8.9) | 77 (19.0) | 0.003 |
| MI, n (%) | 152 (27.1) | 41 (26.1) | 111 (27.4) | 0.83 |
| PVD, n (%) | 61 (10.9) | 15 (9.6) | 46 (11.4) | 0.65 |
| ESKD, n (%) | 373 (66.4) | 96 (61.2) | 277 (68.4) | 0.11 |
| Death, n (%) | 50 (8.9) | 11 (7.0) | 39 (9.6) | 0.41 |
| Cohort using eGFRcys as inclusion criteria | ||||
| Overall, n=598 | White, n=169 | Black, n=429 | P value | |
| Median age (IQR) yrs | 63 (56–69) | 64 (58–70) | 62 (55–68) | 0.12 |
| Female, n (%) | 298 (49.8) | 73 (43.2) | 225 (52.5) | 0.05 |
| Median eGFRa by CKD-EPI (IQR) in ml/min per 1.73 m2 | 16.6 (14.0–18.2) | 17.4 (15.1–18.6) | 16.4 (13.5–18.1) | <0.001 |
| Median urine protein/creatinine ratio (g/g) (IQR) | 0.95 (0.29–2.48) | 0.84 (0.26–2.19) | 0.99 (0.30–2.61) | 0.41 |
| Diabetes, n (%) | 392 (65.6) | 106 (62.7) | 286 (66.7) | 0.39 |
| Heart failure, n (%) | 129 (21.6) | 25 (14.8) | 104 (24.2) | 0.01 |
| MI, n (%) | 207 (34.6) | 62 (36.7) | 145 (33.8) | 0.51 |
| PVD, n (%) | 74 (12.4) | 25 (14.8) | 49 (11.4) | 0.27 |
| ESKD, n (%) | 379 (63.4) | 102 (60.4) | 277 (64.6) | 0.35 |
| Death, n (%) | 82 (13.7) | 26 (15.4) | 56 (13.1) | 0.51 |
| Cohort using eGFRcr-cys as inclusion criteria | ||||
| Overall, n=632 | White, n=177 | Black, n=455 | P value | |
| Median age (IQR) yrs | 62 (55–68) | 64 (55–69) | 62 (54–68) | 0.14 |
| Female, n (%) | 308 (48.7) | 76 (42.9) | 232 (51.0) | 0.08 |
| Median eGFRa by CKD-EPI (IQR) in ml/min per 1.73 m2a | 16.3 (13.5–18.2) | 17.4 (15.4–18.5) | 15.7 (13.0–18.0) | <0.001 |
| Median urine protein/creatinine ratio (g/g) (IQR) | 0.98 (0.30–2.69) | 0.90 (0.27–2.18) | 0.98 (0.33–2.77) | 0.27 |
| Diabetes, n (%) | 402 (63.6) | 105 (59.3) | 297 (65.3) | 0.17 |
| Heart failure, n (%) | 125 (19.8) | 23 (13.0) | 102 (22.4) | 0.008 |
| MI, n (%) | 193 (30.5) | 54 (30.5) | 139 (30.6) | 1.000 |
| PVD, n (%) | 81 (12.8) | 24 (13.6) | 57 (12.5) | 0.79 |
| ESKD, n (%) | 414 (65.5) | 111 (62.7) | 303 (66.6) | 0.40 |
| Death, n (%) | 77 (12.2) | 20 (11.3) | 57 (12.5) | 0.79 |
MI, myocardial infarction; PVD, peripheral vascular disease.
a
Downward adjusted eGFR with application of our adjustment factor to simulate entry of Blacks into the cohort at a higher eGFR threshold.