Table 1.
Clinicopathologic features of EXT1/EXT2-positive and EXT1/EXT2-negative LMN
| Variable | EXT1/EXT2-Positive, n=122 | EXT1/EXT2-Negative, n=252 | P Valuea |
|---|---|---|---|
| Age, yr | Median: 32 | Median: 35 | 0.01 |
| IQR: 25–41 | IQR: 27–45 | ||
| Sex | Male: 16 (13.1%) | Male: 47 (18.7%) | 0.18 |
| Female: 106 (86.9%) | Female: 205 (81.3%) | ||
| SCr at presentation, mg/dl | Median: 0.8 | Median: 0.9 | 0.02 |
| IQR: 0.6–1.2; n=112 | IQR: 0.7–1.4; n=227 | ||
| Proteinuria at presentation, g/24 h | Median: 3.5 | Median: 3 | 0.08 |
| IQR: 2–6.6; n=95 | IQR: 1.8–4.8; n=199 | ||
| Proteinuria ≥3.5 g/d at presentation | 57 (60%); n=95 | 87 (43.7%); n=199 | 0.009 |
| Hematuria | 41 (33.6%) | 87 (34.5%) | 0.86 |
| Other autoimmune disease | 32 (26.2%) | 47 (18.7%) | 0.09 |
| Sclerosed glomeruli, % | Median: 3.8 | Median: 9.1 | 0.001 |
| IQR: 0–12.1 | IQR: 0–24.8 | ||
| IFTA, % | Median: 0 | Median: 10 | <0.001 |
| IQR: 0–10 | IQR: 5–20 | ||
| Proliferative features on light microscopy | 30 (24. 6%) | 81 (32.1%) | 0.13 |
| Immunofluorescence (glomerular staining) | Total cases with immunofluorescence (n=118) | Total cases with immunofluorescence (n=244) | — |
| IgG: 2–3+ (n=118, 100%) | IgG (n=244, 100%): | ||
| IgA (n=89, 75.4%); | trace (n=3); | ||
| trace (n=17); | 1+ (n=8); | ||
| 1+ (n=22); | 2–3+ (233) | ||
| 2–3+ (50) | IgA (n=186, 76.2%): | ||
| IgM (n=103, 87.3%): | trace (n=35); | ||
| trace (n=23); | 1+ (n=53); | ||
| 1+ (n=32); | 2–3+ (98) | ||
| 2–3+ (48) | IgM (n=220, 90.2%): | ||
| C1q (n=107, 90.7%): | trace (n=27); | ||
| trace (n=18); | 1+ (n=75); | ||
| 1+ (n=20); | 2–3+ (118) | ||
| 2–3+ (69) | C1q (n=216, 88.5%): | ||
| C3 (n=117, 99.2%): | trace (n=38); | ||
| trace (n=2); | 1+ (n=39); | ||
| 1+ (n=6); | 2–3+ (139) | ||
| 2–3+ (109) | C3 (n=238, 97.5%): | ||
| κ light chain (n=118, 100%): | trace (n=11); | ||
| trace (n=3); | 1+ (n=29); | ||
| 1+ (n=8); | 2–3+ (198) | ||
| 2–3+ (107) | κ light chain (n=241, 98.8%): | ||
| λ light chain (n=118, 100%): | trace (n=12); | ||
| trace (n=1); | 1+ (n=31); | ||
| 1+ (n=1); | 2–3+ (198) | ||
| 2–3+ (116) | λ light chain (n=241, 98.8%): | ||
| trace (n=10); | |||
| 1+ (n=22); | |||
| 2–3+ (209) | |||
| Electron microscopy | Subepithelial deposits: 122 (100%), of which 62 (50.8%) also had intramembranous deposits | Subepithelial deposits: 250 (99.2%), of which 153 (61.2%) also had intramembranous deposits | — |
| Mesangial/paramesangial deposits: 116 (95.1%) | Intramembranous deposits only: 2 (0.8%) | ||
| Subendothelial deposits: 71 (58.2%) | Mesangial/paramesangial deposits: 239 (94.8%) | ||
| Tubuloreticular inclusions: 107 (87.7%) | Subendothelial deposits: 146 (57.9%) | ||
| Tubuloreticular inclusions: 199 (79.0%) |
a
P<0.05 is considered significant.