Figure 2.

Single-cell survey of the human urine. (A) Uniform Manifold Approximation and Projection (UMAP) dimension reduction of 23,089 urinary cells identified in 17 DKD and one pooled control urine samples. Clusters 0, 2, 8, 9, 10, 11, 15, 16, 19, and 20 were called Epi. (B) Bubble dot plots of the top cluster specific genes. The size of the dot indicates expression percentage and the darkness of the color indicates average expression. Epi, variety epithelial cells; Epi-PLAT⁺, PLAT-positive cells; Epi-KRT1⁺, KRT1-positive cells; umbrella, umbrella cells; endo, endothelial cells; podo, podocytes; LOH, loop of Henle; fibro, fibroblast; CD, collecting duct principal cell; macro, macrophages; lympho, lymphocytes; mes, mesenchymal cells.