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. 2021 Feb 16;10(2):302. doi: 10.3390/antiox10020302

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A schematic model for the effect of 12/15s-HpETE and Prx III on the redox regulation of PTEN. Prx III plays an important role in the control of endogenous lipid peroxide-induced redox regulation of PTEN. 12/15s-HpETE inhibits the Trx redox system by inducing dimerization of Trx, resulting in the delayed reduction of oxidized PTEN and oxidized Prx. Prx III prevents 12/15s-HpETE-mediated PTEN oxidation by catalyzing the reduction of lipid peroxide. Black arrows (activating), red arrows (blocking).