Table 1.

Summary of the characteristic transcriptional profile of tissue–resident memory T cells (T_RM). In this table, a selection of transcripts that are part of the key transcriptional profile displayed by T_RM is shown. It must be noted that the markers displayed in this table do not occur on every population of T_RM.

Transcript	Gene	Up- (↑) or Down (↓) Regulated	Expression-Human vs. Mouse	References
	Surface markers
CD69	Cd69	↑	Both	[3,9,10]
CD103	Itgae	↑	Both	[3,9,10]
CD49a	Itga1	↑	Both	[3,9,10]
CD101	Cd101	↑	Both	[3]
CD62L	Sell	↓	Human	[3,9,10]
CXCR6	Cxcr6	↑	Both	[3,10]
CX3CR1	Cx3cr1	↑	Human	[3]
CCR7	Ccr7	↓	Human	[3,9]
PD-1	Pdcd1	↑	Human	[3,10]
S1PR1	S1pr1	↓	Both	[3,9,10]
	Intracellular proteins
DUSP6	Dusp6	↑	Both	[3,10]
KLF2	Klf2	↓	Both	[3,10]
KLF3	Kl3	↓	Human	[3,10]
Eomes	Eomes	↓	Human	[9,11]
T-bet	Tbx21	↓ *	Human	[11]
Blimp1	Prdm1	↑	Mouse	[12]
Hobit	Zfp683	↑	Mouse	[12]
Runx3	Runx3	↑	Mouse & Human TIL **	[13]
Id3	Id3	↑	Mouse	[14]
Nr4a1	Nr4a1	↑	Human	[9]

* T-bet is downregulated, but some expression of T-bet is required for T_RM survival [9]. ** TIL-tumor infiltrating lymphocytes.