Figure 2.
Impact of the CXCR4 S338X WM mutation on growth. (A) Increased proliferation of BCWM.1 cells transduced with CXCR4 S338X. Absolute cell numbers were determined after 24, 48 and 72 h using Trypan blue for live-dead staining. Mean values (±SEM) of three independent experiments are shown (** p < 0.002; * p < 0.03). (B) Increased colony formation ability of MWCL-1 cells transduced with CXCR4 S338X. Mean values (± SEM) of three independent experiments performed in duplicates are shown without and in addition of CXCL12 (**** p < 0.0001).