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. 2021 Feb 16;13(4):826. doi: 10.3390/cancers13040826

Figure 4.

Figure 4

Optimized EPI-X4 derivatives impair migration and prolong survival of NSG mice transplanted with WM cells. (A) WSC02 reduces CXCL12-directed transwell migration of BCWM.1 WT cells at a concentration of 10 µM more efficiently than EPI-X4 at a concentration of 200 µM. In comparison to AMD3100 at a concentration of 10µM the efficiency of WSC02 is to a similar degree (Ordinary one-way Anova ** p < 0.003; *** p < 0.0007). (B) WSC02 and JM#21 suppress migration of BCWM cells stably expressing CXCR4 iso1 WT or CXCR4 S338X at a concentration of 10 µM. All values represent mean values ± SEM of migrated cells relative to CXCL12-only treated cells from three independent experiments (** p < 0.009). (C) Survival of mice injected with MWCL-1 cells treated with the indicated peptides. Median survival: Untreated: 56 days; Inactive CTL: 54.5 days; EPI-X4: 65 days, WSC02: 90 days. Log-rank (Mantel-Cox) test: Untreated/Inactive control (n = 5) compared to WSC02 (n = 3) (* p < 0.01).