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Inhibition of ERK and AKT signaling by EPI-X4 and its optimized derivatives in WM cells. (A) ERK and (B) AKT phosphorylation in WM cells upon incubation with EPI-X4 and its optimized derivatives. Cells were stimulated with CXCL12 and incubated with the different peptides. Cells were analyzed by flow cytometry with FACS Cytoflex for phosphorylation of Erk1/Erk2 (n = 3–5). (* p < 0.1, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns = not significant).
