Table 1.

The effect of size, poly dispersity index, encapsulation efficiency (%) and loading content (%), and zeta potential on chitosan: Sorafenib ratios. Optimal parameters are shown in bold.

Sample	Chitosan: Sorafenib ratio (mg/mL)	Size (nm)	PDI	EE (%)	LC (%)	Zeta Potentials (mV)
SF-CS NPs	5:0	10.5 ± 9.6	0.22	0.0 ± 0.0	0.0 ± 0.0	7.9 ± 0.9
	5:1	27.2 ± 12.6	0.19	20.2 ± 1.2	7.7 ± 0.5	8.7 ± 0.4
	5:2	30.8 ± 11.9	0.23	69.8 ± 3.3	12.2 ± 0.2	19.8 ± 0.4
	5:3	76.3 ± 13.7	0.28	83.7 ± 2.4	18.2± 1.3	31.5 ± 0.6
	5:4	67.9 ± 11.2	0.10	79.9 ± 1.9	14.8 ± 1.0	32.8 ± 0.5
	5:5	28.7 ± 7.8	0.45	49.8 ± 0.9	7.6 ± 0.6	37.7 ± 0.4
	5:6	15.4 ± 9.8	0.68	19.4 ± 1.3	6.9 ± 0.1	37.6 ± 0.1
	5:7	27.8 ± 5.0	0.92	3.7 ± 1.1	12.9 ± 0.4	31.8 ± 0.3
	5:8	14.9 ± 5.9	2.07	8.8 ± 0.5	6.0 ± 0.6	25.4 ± 0.7
	1:3	18.5 ± 7.3	0.09	9.8 ± 0.6	1.9 ± 0.0	17.6 ± 0.9
	2:3	47.6 ± 3.9	0.05	6.9 ± 0.9	8.9 ± 0.5	11.3 ± 0.8
	4:3	52.5 ± 4.2	1.19	9.0 ± 1.1	3.2 ± 0.6	27.9 ± 0.5
	6:3	66.3 ± 8.2	0.34	55.9 ± 2.6	12.9 ± 1.7	21.2 ± 0.5
	7:3	139.2 ± 2.7	0.21	34.9 ± 2.3	14.4 ± 1.7	34.4 ± 0.7
	8:3	120.2 ± 2.9	0.49	45.6 ± 1.9	9.9 ± 1.2	29.1 ± 0.4
	9:3	201.0 ± 3.8	5.07	19.7 ± 1.2	6.9 ± 1.8	24.7 ± 0.5