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. 2021 Feb 16;22(4):1954. doi: 10.3390/ijms22041954

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Spontaneous features of neurofibromatosis (NF) in cows. Bovine peripheral nerve sheath tumor (PNST) (A) and cutaneous neurofibroma (B–D). (A) PNST. Two tumors (arrows) located in relation to intercostal nerves (not visible). Specimen displaying the internal surface of the thorax. R: rib [42]. (B) Cutaneous neurofibroma. Note the firm exophytic nodule with marked ulceration in the paralumbar fossa. Inset: Nodule after complete surgical excision [54]. (C) Cutaneous neurofibroma. Note the mesenchymal cell proliferation forming plexiform beams. Hematoxylin-Eosin. ×200 [54]. (D) Cutaneous neurofibroma. Positive immunoblotting for S-100, counterstained with Harris Hematoxylin. ×400 [54].

Spontaneous features of neurofibromatosis (NF) in cows. Bovine peripheral nerve sheath tumor (PNST) (A) and cutaneous neurofibroma (B–D). (A) PNST. Two tumors (arrows) located in relation to intercostal nerves (not visible). Specimen displaying the internal surface of the thorax. R: rib [42]. (B) Cutaneous neurofibroma. Note the firm exophytic nodule with marked ulceration in the paralumbar fossa. Inset: Nodule after complete surgical excision [54]. (C) Cutaneous neurofibroma. Note the mesenchymal cell proliferation forming plexiform beams. Hematoxylin-Eosin. ×200 [54]. (D) Cutaneous neurofibroma. Positive immunoblotting for S-100, counterstained with Harris Hematoxylin. ×400 [54].