Table 1.
GEMM of NF1-associated clinical manifestations using the Cre-Lox system.
| Genotype | Cell Type | Phenotype | Reference |
|---|---|---|---|
| GFAP-Cre; Nf1flox/mut | Astrocytes | Optic pathway glioma | [77] |
| P0A-Cre;Nf1flox/− | Nonmyelinating SCs | Plexiform neurofibroma | [78] |
| Plp-CreER;Nf1flox/flox | Schwann cell precursors (SCPs) | Plexiform neurofibroma | [79] |
| Krox20-Cre;Nf1flox/− | SCPs | Plexiform neurofibroma | [80] |
| Dhh-Cre;Nf1flox/flox | SCPs | Plexiform/cutaneous neurofibroma | [81] |
| Dhh-Cre;Nf1flox/flox; Ink4a/Arf+/−; Ink4a/Arf−/−; Ink4a/Arfflox/flox | SCPs | atypical neurofibroma, MPNST | [82] |
| CMV-CreER T2;Rosa26;Nf1flox/− |
Skin-derived precursors (SKPs) | Cutaneous neurofibroma | [83] |
| Hoxb7-Cre;Nf1flox/flox;LacZ | SKPs | Cutaneous/plexiform neurofibroma | [84] |
| Prss56-Cre;Rosa26-tdTom;Nf1flox/flox | Boundary cap cells | Cutaneous/plexiform neurofibroma | [85] |
| Postn-Cre;Nf1flox/flox;Arf flox/+ | SCPs | Plexiform neurofibroma, atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP), MPNST | [86] |
| Mx1-Cre; Nf1flox/flox | Bone marrow | JMML | [87] |
| CAD5-CreERT2/Rosa26-LSL-td-Tomato; Nf1flox/flox | Vascular endothelium | Altered proliferation and morphogenesis | [88] |
| Col2α1-Cre; Nf1flox/flox | Chondrocytes | Skeletal dysplasia | [89] |