Fig 5. DNase I treatment against NE can abrogate the invasion-boosting effects of neutrophils (Experimental data [22] and simulation results).

(A) NE levels in the system in the absence (control) and presence (⁺TAN) of neutrophils, and DNase treatment (⁺TAN⁺D) cases at t = 22 h. (B) Experimental data from the invasion assay in [22] (left column; 4T1 cancer cells) and computational results from mathematical model (right column). The graph shows the (scaled; %) population of invasive tumor cells at t = 22 h in the absence (control; blue) and presence (⁺TAN; red shaded) of neutrophils, and DNase treatment (⁺TAN⁺D; yellow dotted) cases. Addition of DNase I reduces the number of invading tumor cells by almost 50%.