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. 2021 Feb 17;17(2):e1008257. doi: 10.1371/journal.pcbi.1008257

Fig 10. Inhibition of CXCL8 reduces proliferation, viability and invasion (Experiments vs simulation results).

Fig 10

(A) Time course of cell proliferation shows a drastic decrease in the LS174T cell population with CXCL8 knockdown (shCXCL8; blue) compared to control (LS174T) in in vivo experiments [100]. Model simulation shows a consistent, significant reduction of the tumor cell proliferation in the CXCL knockdown case (CXCL8-KO; blue) compared to control, abrogating tumor growth. (B) CXCL8 knockdown significantly decreases the invasiveness of LS174T cells (blue) [100], as our model simulation illustrates (red).