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. 2021 Feb 17;17(2):e1008257. doi: 10.1371/journal.pcbi.1008257

Table 2. Parameters used in the tumor model.

Continued from Table 1.: Dimensionless values were marked in *.

Description Dimensional Value Refs.
Degradation/Decay rates
KM Hill coefficient of MMP degradation by TIMP 4.64 × 10−8 g/cm3 [156], estimated
m Hill coefficient of MMP degradation by TIMP 2 estimated
Movement parameters (chemotaxis, haptotaxis)
χE Chemotactic sensitivity to NE 1.117 × 10−9 cm.s−1 [22, 33, 130, 157]
δE Scaling parameter of NE gradient (|E|) 6.46 × 10−8 g/cm4 estimated
σE Scaling parameter of NE gradient (|E|) 1.0 estimated
χρ Haptotactic sensitivity 3.5 × 10−10 cm.s−1 [22, 158160], estimated
δρ Scaling parameter of ECM gradient (|ρ|) 5.0 × 10−3 g/cm4 estimated
σρ Scaling parameter of ECM gradient (|ρ|) 1.0 estimated
χ1C Chemotactic sensitivity of N1 neutrophils to CXCL8 1.1 × 10−9 cm.s−1 [22, 33, 161], estimated
δ1 Scaling parameter of CXCL gradient (|C|) 1.0 × 10−11 g/cm4 estimated
χ2C Chemotactic sensitivity of N2 neutrophils to CXCL8 1.1 × 10−9 cm.s−1 [22, 33, 161], estimated
δ2 Scaling parameter of CXCL gradient (|C|) 1.0 × 10−11 g/cm4 estimated
σC Scaling parameter of CXCL8 gradient (|C|) 1.0* estimated
Membrane parameters
γc permeability of cells (Tumor cells, N1 neutrophils, N2 neutrophils) 0.01-785 (78.5)* estimated
γ permeability of chemicals (CXCL8, TGF-β, NET/NE, NE inhibitor, MMP, TIMP) 0.1-7850 (785)* [33], estimated
μ ECM width 0.6* estimated