Degradation/Decay rates |
KM
|
Hill coefficient of MMP degradation by TIMP |
4.64 × 10−8
g/cm3
|
[156], estimated |
m |
Hill coefficient of MMP degradation by TIMP |
2 |
estimated |
Movement parameters (chemotaxis, haptotaxis) |
χE
|
Chemotactic sensitivity to NE |
1.117 × 10−9
cm.s−1
|
[22, 33, 130, 157] |
δE
|
Scaling parameter of NE gradient (|E|) |
6.46 × 10−8
g/cm4
|
estimated |
σE
|
Scaling parameter of NE gradient (|E|) |
1.0 |
estimated |
χρ
|
Haptotactic sensitivity |
3.5 × 10−10
cm.s−1
|
[22, 158–160], estimated |
δρ
|
Scaling parameter of ECM gradient (|ρ|) |
5.0 × 10−3
g/cm4
|
estimated |
σρ
|
Scaling parameter of ECM gradient (|ρ|) |
1.0 |
estimated |
|
Chemotactic sensitivity of N1 neutrophils to CXCL8 |
1.1 × 10−9
cm.s−1
|
[22, 33, 161], estimated |
δ1
|
Scaling parameter of CXCL gradient (|C|) |
1.0 × 10−11
g/cm4
|
estimated |
|
Chemotactic sensitivity of N2 neutrophils to CXCL8 |
1.1 × 10−9
cm.s−1
|
[22, 33, 161], estimated |
δ2
|
Scaling parameter of CXCL gradient (|C|) |
1.0 × 10−11
g/cm4
|
estimated |
σC
|
Scaling parameter of CXCL8 gradient (|C|) |
1.0* |
estimated |
Membrane parameters |
γc
|
permeability of cells (Tumor cells, N1 neutrophils, N2 neutrophils) |
0.01-785 (78.5)* |
estimated |
γ |
permeability of chemicals (CXCL8, TGF-β, NET/NE, NE inhibitor, MMP, TIMP) |
0.1-7850 (785)* |
[33], estimated |
μ |
ECM width |
0.6* |
estimated |