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. 2021 Feb 16;11(2):132. doi: 10.3390/jpm11020132

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Intestinal obstruction is a common phenotype in CF rabbits. (A) Gross images of the GI tracks of a CF rabbit. The proximal colon (highlighted in blue) was dilated. Red arrow indicates the point of blockage. (B) Gross images of the GI tracks of a WT rabbit. Blue arrow indicates feces pellets, which are missing in the CF rabbit. (C) AB-PAS staining of the cross section of a CF rabbit colon. (D) AB-PAS staining of the cross section of a WT rabbit colon. (E) AB-PAS staining of the longitudinal sections of a CF rabbit colon. Region within the box is a representative area of interstitial fibrosis. Arrows indicate inflammatory infiltration; asterisks indicate goblet cell hyperplasia. (F) AB-PAS staining of the longitudinal sections of a WT rabbit colon. S: stomach. R: rectum. -/-: CFTR-/-. +/+: CFTR+/+.