. 2021 Feb 16;10(4):799. doi: 10.3390/jcm10040799

Table 3.

Subgroup analysis of the risk of Crohn’s disease and ulcerative colitis among people with dipstick-positive proteinuria.

Subgroup	Crohn’s Disease		Ulcerative Colitis
Subgroup	Adjusted HR ^† (95% CI)	p for Interaction	Adjusted HR ^† (95% CI)	p for Interaction
Age, years
20–64	1.732 (1.27–2.361)	0.828	0.903 (0.741–1.101)	0.068
65–110	1.459 (0.708–3.003)	0.828	1.33 (0.886–1.996)	0.068
Sex
Male	1.515 (1.032–2.224)	0.099	0.984 (0.794–1.221)	0.489
Female	2.099 (1.38–3.194)	0.099	0.899 (0.657–1.231)	0.489
eGFR, mL/min/1.73 m²
≥ 90	1.703 (1.063–2.728)	0.340	0.945 (0.693–1.287)	0.552
60–90	1.46 (0.952–2.238)		0.923 (0.721–1.181)
< 60	2.217 (1.109–4.431)		1.303 (0.818–2.078)
Regular exercise ^‡
No	1.726 (1.162–2.564)	0.938	1.102 (0.869–1.397)	0.143
Yes	1.633 (1.083–2.462)	0.938	0.831 (0.635–1.086)	0.143
Obese ^§
No	1.765 (1.255–2.452)	0.711	0.987 (0.794–1.228)	0.912
Yes	1.482 (0.863–2.546)	0.711	0.922 (0.68–1.251)	0.912
Diabetes mellitus
No	1.532 (1.099–2.135)	0.171	0.846 (0.687–1.041)	0.004
Yes	2.28 (1.281–4.057)	0.171	1.527(1.073–2.174)	0.004
Hypertension
No	1.617 (1.111–2.355)	0.572	0.936(0.738–1.188)	0.720
Yes	1.751 (1.127–2.719)	0.572	0.987(0.755–1.288)	0.720

CI, confidence interval; HR, hazard ratio; eGFR, estimated glomerular filtration rate. ^† Age, sex, income level, smoking status, alcohol consumption status, exercise level, body mass index, estimated glomerular filtration rate, diabetes mellitus, hypertension, and dyslipidemia adjusted. ^‡ Defined as high-intensity exercise for at least 20 min or moderate-intensity exercise for at least 30 min at a time at least once a week. ^§ Defined as a body mass index ≥ 25 kg/m².