Table 5.
Univariate and Multivariate Cox Analyses of the Associations Between Prognostic Signatures and Overall Survival in Breast Cancer
| Clinical Variables | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age | 1.61 | 1.12–2.33 | 0.011 | 1.31 | 0.88–1.94 | 0.071 |
| Histological type | 1.03 | 0.82–1.98 | 0.712 | |||
| Stage | 2.19 | 1.74–2.76 | <0.001 | 1.90 | 1.62–2.63 | 0.032 |
| T | 1.43 | 1.17–1.75 | <0.001 | 1.39 | 1.09–1.70 | 0.097 |
| N | 1.63 | 1.37–1.95 | <0.001 | 1.51 | 1.23–1.88 | 0.002 |
| M | 4.81 | 2.86–8.07 | <0.001 | 3.98 | 2.01–7.78 | <0.001 |
| ER status | 0.93 | 0.67–1.33 | 0.129 | |||
| PR status | 1.02 | 0.76–1.35 | 0.341 | |||
| Her-2 status | 1.29 | 0.99–1.87 | 0.432 | |||
| TNBC | 0.88 | 0.48–1.51 | 0.118 | |||
| MRPL13 | 1.98 | 1.19–2.97 | 0.002 | 1.82 | 1.09–2.38 | 0.006 |
Abbreviations: ER, estrogen receptor; PR, progesterone receptor; Her-2, human epidermal growth factor receptor-2; TNBC, triple-negative breast cancer; IDC, infiltrating ductal carcinoma; ILC, infiltrating lobular carcinoma.