Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 29;3(1):vdaa149. doi: 10.1093/noajnl/vdaa149

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 3. — JHU-083 reduces cell growth independently of glutaminolysis. (A) BrdU incorporation into DNA was analyzed in glioma cells treated with JHU-083 (24 h). (B) ATP, Gln, Glu, glutathione, GSH/GSSH ratio, and lactate levels were determined in glioma cells treated with JHU-083 (24 h). (C) Cell viability were performed in BT142 treated with JHU-083 in combination with NAC (4 mM), GSH (4 mM), Glu (4 mM), DM-αKG (10 mM), AGI-5198 (1 µM), and Chloroquine (20 µM) for 72 h. AGI: AGI-5198. Chlo: Chloroquine. *P < .05; **P < .01; ***P < .001; ****P < .0001 versus Control.