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. 2020 Oct 29;3(1):vdaa149. doi: 10.1093/noajnl/vdaa149

Figure 5.

Figure 5.

Cell proliferation, DNA synthesis, and mTOR signaling pathway are partially restored in cells cotreated with JHU-083 and guanine. (A) Cell viability was performed in cells treated with JHU-083 in combination with guanine or adenine (96 h). (B) Cell viability was performed in cells treated with Don in combination with guanine (96 h). (C) BrdU incorporation in BT142 treated with JHU-083 in combination with guanine (24 h). (D) Protein expression in BT142 treated with JHU-083 and guanine (24 h). (E) Cells were treated with JHU-083 (24 h) in combination with guanine and/or everolimus at indicated concentration and protein expression was analyzed by Western blot. (F) Cell viability was performed in BT142 treated with JHU-083 in combination with guanine and everolimus (96 h). *P < .05; **P < .01; ***P < .001; ****P < .0001 versus respective control.