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JHU-083 extends survival in orthotopic IDH1R132H glioma. (A) Kaplan–Meier survival curve of BT142 in orthotopic xenograft treated with vehicle solution or JHU-083 (1.9 mg/kg or 25 mg/kg; n = 5 group). (B) Representative images of H&E, IDH1R132H, and pS6(ser235/236) immunohistochemistry. Scale bar 50 µm.
