Table 1.
Characteristics of Patients with Multiple Myeloma
| Variables | Total Patients (n=861) | PE-Positive Group (n=368) | PE-Negative Group (n=493) | P value* |
|---|---|---|---|---|
| Age, years | 59 (52–66) | 60 (54–68) | 58 (51–65) | 0.002 |
| Male, No. (%) | 497 (57.7) | 226 (61.4) | 271 (55.0) | 0.068 |
| CCI | 3 (2–4) | 3 (2–5) | 3 (2–4) | <0.001 |
| Monoclonal protein type, n (%) | 0.957 | |||
| IgG | 412 (47.9) | 176 (47.8) | 236 (47.9) | |
| IgA | 172 (20.0) | 75 (20.4) | 97 (19.7) | |
| IgD | 58 (6.7) | 27 (7.3) | 31 (6.3) | |
| Light chain | 189 (22.0) | 78 (21.2) | 111 (22.5) | |
| Others | 30 (3.5) | 12 (3.3) | 18 (3.7) | |
| DS stage, n (%) | 0.015 | |||
| I | 32 (3.7) | 12 (3.3) | 20 (4.1) | |
| IIA | 79 (9.2) | 30 (8.2) | 49 (9.9) | |
| IIB | 13 (1.5) | 5 (1.4) | 8 (1.6) | |
| IIIA | 575 (66.8) | 232 (63.0) | 343 (69.6) | |
| IIIB | 162 (18.8) | 89 (24.2) | 73 (14.8) | |
| ISS stage, n (%) | <0.001 | |||
| I | 139 (16.1) | 44 (12.0) | 95 (19.3) | |
| II | 305 (35.4) | 111 (30.2) | 194 (39.3) | |
| III | 417 (48.4) | 213 (57.9) | 204 (41.4) | |
| Del(17p) | 0.349 | |||
| No | 541 (62.8) | 228 (62.0) | 313 (63.5) | |
| Yes | 60 (7.0) | 31 (8.4) | 29 (5.9) | |
| Unknown | 260 (30.2) | 109 (29.6) | 151 (30.6) | |
| Gain(1q21) | 0.911 | |||
| No | 358 (41.6) | 156 (42.4) | 202 (41.0) | |
| Yes | 243 (28.2) | 103 (28.0) | 140 (28.3) | |
| Unknown | 260 (30.1) | 109 (29.6) | 151 (30.6) | |
| t(4;14) | 0.343 | |||
| No | 515 (59.8) | 228 (62) | 287 (58.2) | |
| Yes | 86 (10.0) | 31 (8.4) | 55 (11.2) | |
| Unknown | 260 (30.2) | 109 (29.6) | 151 (30.6) | |
| t(14;16) | 0.929 | |||
| No | 579 (67.2) | 250 (67.9) | 329 (66.7) | |
| Yes | 22 (2.6) | 9 (2.4) | 13 (2.6) | |
| Unknown | 260 (30.2) | 109 (29.6) | 151 (30.6) | |
| t(11;14) | 0.929 | |||
| No | 513 (59.6) | 222 (60.3) | 291 (59.0) | |
| Yes | 88 (10.2) | 37 (10.1) | 51 (10.3) | |
| Unknown | 260 (30.2) | 109 (29.6) | 151 (30.6) |
Notes: Data are presented as median (interquartile range) or %. *For comparisons between PE-negative group and PE-positive group.
Abbreviations: PE, pleural effusion; CCI, Charlson Comorbidity Index; DS, Durie-Salmon; ISS, International Scoring System.