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. 2021 Feb 25;14:1261–1273. doi: 10.2147/OTT.S283548

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© 2021 Wang et al.

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Transcriptome sequencing analysis of ouabain-mediated inhibitory functions in A375 cells. A375 cells were treated with 100 μM ouabain for 48 hours, and the samples were collected using TRIzol reagent for transcriptome sequencing. (A). The heatmaps of gene expression data from transcriptome analysis. (B). The volcano plots showed the DEGs between control and ouabain treatment groups. (C). The bubble diagram of top 20 ranked GO terms of DEGs. (D). KEGG pathway enrichment analysis of the genes affected by ouabain as described in (A).