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. 2021 Feb 25;14:551–565. doi: 10.2147/JIR.S279249

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© 2021 Cai et al.

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Diagrammatic representation of effect of Hyp on Bach1 and Nrf2. (A) Normal conditions; (B–D) After oxidative stress, Hyp promotes the nuclear accumulation of Nrf2 and the nuclear export of Bach1, and thus contributes to the activation of their target genes Crm1 (XPO1) and HO-1 (HMOX1).