Table 1.
Effect of Hyp on Serum AST and ALT Levels and Liver MDA, SOD and GSH Activities in Acute Liver Injury Mice Induced by CCl4
| Group | ALT (karU) |
AST (karU) |
MDA (nmol/mgprot) |
SOD (U/mgprot) |
GSH (mg/gprot) |
Liver Index |
|---|---|---|---|---|---|---|
| Normal | 27.78±4.15 | 36.49±14.18 | 22.47±3.37 | 365.63±38.03 | 4.37±0.58 | 5.03±0.31 |
| CCl4 | 299.16±52.64* | 359.16±74.75* | 41.97±6.17* | 247.52±52.74* | 2.58±0.66* | 7.87±0.56* |
| Bif | 86.71±22.87*** | 151.27±36.41*** | 33.7±4.03** | 343.40±38.81** | 3.83±0.60*** | 6.77±0.45*** |
| Hyp-L | 226.04±70.23 | 221.16±64.96** | 35.87±5.10 | 315.88±43.11 | 3.28±0.65 | 7.32±0.52 |
| Hyp-H | 139.81±56.96*** | 166.63±52.25*** | 31.52±4.42*** | 338.32±42.24*** | 3.65±0.52** | 6.52±0.63*** |
Notes: *P<0.01 compared with normal control group; **P<0.05, ***P<0.01 as compared with CCl4 control group (
± s, n=6).
Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; MDA, malondialdehyde; SOD, superoxide dismutase; GSH, glutathione.