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. 2021 Mar;27(3):779–788. doi: 10.3201/eid2703.203482

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Kaplan–Meier and log-rank (Mantel–Cox) pairwise analyses of survival of patients with Candida glabrata candidemia, based on patient data and cultures collected during a multicenter surveillance study, South Korea, 2008–2018. A) Cumulative survival curves of 64 patients infected with fluconazole-resistant (FR) bloodstream infection (BSI) isolates. The cumulative mortality rates of 64 patients infected with FR C. glabrata BSIs increased over time (day 7 [29.7%], day 30 [60.9%], day 60 [68.8%], and day 90 [78.1%]). B) Cumulative survival curves of patients infected with fluconazole-susceptible dose-dependent (F-SDD) BSI isolates (297 patients total) in 2009 (75 patients in 6 hospitals), 2014 (97 patients in 7 hospitals), 2017 (75 patients in 9 hospitals), and 2018 (50 patients in 8 hospitals). The 30-day mortality rate of the F-SDD group was 34.7% in 2010, 39.2% in 2014, 37.3% in 2017, and 32.0% in 2018. The cumulative mortality rates of 297 patients infected with F-SDD BSI isolates of C. glabrata were found to be 18.5% at day 7 (p = 0.084), 36.4% at day 30 (p = 0.001), 41.8% at day 60 (p<0.001), and 43.8% at day 90 (p<0.001).