Table 2. Pdr1 AAS in 66 FR isolates and 212 F-SDD BSI isolates of Candida glabrata and their MLST genotypes, based on cultures collected during a multicenter surveillance study, South Korea, 2008–2018*.
| MLST genotype | Fluconazole susceptibility | No. isolates tested | No. with echinocandin resistance | No. isolates with 5 Pdr1p AAS found in both FR and F-SDD isolates |
No. isolates with additional Pdr1p AAS except for 5 Pdr1p AAS |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P76S | P143T | D243N | E259G | T745A | 1 | 2 | Total | |||||
| ST7 | FR | 37 | 6† | 34 | 3 | 37 | ||||||
|
|
F-SDD |
98 |
3 |
|
|
|
|
|
|
0 |
|
0 |
| ST3 | FR | 7 | 0 | 7 | 7 | 7 | 6 | 1 | 7 | |||
|
|
F-SDD |
43 |
1 |
43 |
43 |
43 |
|
|
|
0 |
|
0 |
| ST26 | FR | 7 | 0 | 6 | 6 | |||||||
|
|
F-SDD |
10 |
1 |
|
|
|
|
|
|
0 |
|
0 |
| ST22 | FR | 1 | 0 | 1 | 1 | |||||||
|
|
F-SDD |
16 |
1 |
|
|
|
|
|
|
0 |
|
0 |
| ST10 | FR | 2 | 0 | 2 | 2 | |||||||
|
|
F-SDD |
9 |
0 |
|
|
|
|
|
|
0 |
|
0 |
| ST55 | FR | 2 | 0 | 2 | 2 | 2 | ||||||
|
|
F-SDD |
6 |
1 |
|
|
|
6 |
|
|
1 |
|
1 |
| ST2 | FR | 2 | 0 | 2 | 2 | |||||||
|
|
F-SDD |
3 |
0 |
|
|
|
|
|
|
0 |
|
0 |
| ST6 | FR | 1 | 0 | 1 | 1 | |||||||
|
|
F-SDD |
5 |
2 |
|
|
|
|
|
|
0 |
|
0 |
| ST59 | FR | 1 | 0 | 1 | 1 | 1 | ||||||
|
|
F-SDD |
3 |
1 |
|
|
|
|
3 |
|
0 |
|
0 |
| ST1 |
FR |
2 |
0 |
|
|
|
|
|
|
2 |
|
2 |
| ST12 |
F-SDD |
2 |
0 |
|
|
|
|
|
|
0 |
|
0 |
| Other STs‡ |
FR | 4 | 0 | 1 | 2 | 2 | 4 | |||||
| F-SDD |
17 |
0 |
2 |
2 |
2 |
|
|
|
1 |
|
1 |
|
| Total, no. (%) | FR | 66 | 6 | 7 | 7 | 7 | 3 | 1 | 59 | 6§ | 65 (98.5) | |
| F-SDD | 212 | 10 | 45 | 45 | 45 | 6 | 3 | 2¶ | 2 (0.9) | |||
*AAS, amino acid substitution; BSI, bloodstream infection; FR, fluconazole-resistant; F-SDD, fluconazole-susceptible dose-dependent; MLST, multilocus sequence typing; ST, sequence type. †All 6 isolates showed multidrug resistance, defined as resistance to both fluconazole and echinocandins. ‡Includes 21 STs that were each unique to a single isolate. §Each of 6 FR isolates harbored 2 additional Pdr1 AAS (E340G/D919Y [ST7], Y556C/F580I [ST7], N132S/G1099S [ST7], F832L/L833V [ST3], G189V/E340G [other ST], and L366P/E555D [other ST]). ¶Two F-SDD isolates harbored additional Pdr1 AAS (V502I [ST55] and R250K [other ST]).