FIG 5.

Drug resistance-associated mutations in CMV genes. CMV gene mutation maps for UL54, UL97, and UL56 show structural domains and the locations of identified resistance mutations. Color-coding indicates the resistance phenotype (A and B) and the degree of resistance conferred (C). GCVr, ganciclovir resistant; CDVr, cidofovir resistant; FOSr, foscarnet resistant; MBV-R, maribavir resistant; ZF, zinc finger; LZ, leucine zipper; NLS, nuclear localization signal; EC50, 50% effective concentration. (Reproduced from reference 190 with permission of Elsevier.)