Table 1.
Comparison of redox parameters between SCA2 mutation carriers and control individuals.
| Redox parameters | Controls (n = 36) | Presymptomatics (n = 36) | Patients (n = 36) | F | p | |||
|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | |||
| SOD3 (KU/L) | 2.02 | 0.52 | 1.85 | 0.46 | 1.99 | 0.38 | 1.46 | 0.238 |
| CAT (KUI/L) | 19.14 | 8.74 | 15.48 | 7.68 | 20.00 | 13.81 | 1.91 | 0.153 |
| CAT/SOD3 | 9.97 | 5.46 | 9.30 | 6.39 | 10.35 | 6.86 | 0.26 | 0.773 |
| GST (UI/L) | 14.00 | 4.73 | 11.54 | 5.08 | 15.09 | 4.98 | 4.88 | 0.009 |
| R-SH (μmol/L) | 136.92 | 71.29 | 105.09 | 43.30 | 124.32 | 63.17 | 2.54 | 0.084 |
| TBARS (μmol/L) | 2.17 | 0.72 | 1.90 | 0.72 | 1.97 | 1.07 | 0.88 | 0.420 |
| PC (nmol/mg) | 1.65 | 0.43 | 1.74 | 0.41 | 1.48 | 0.43 | 3.30 | 0.041 |
| DS | 0.03 | 0.74 | −0.11 | 0.83 | −0.44 | 0.86 | 3.20 | 0.045 |
| PS | −0.01 | 0.51 | −0.49 | 0.50 | 0.01 | 0.41 | 12.75 | <0.001 |
| OXY score | 0.04 | 0.97 | 0.38 | 0.87 | −0.46 | 0.97 | 7.29 | 0.001 |
SOD3: superoxide dismutase activity; CAT: catalase activity; GST: glutathione S-transferase activity; R-SH: reducing thiol total concentration; TBARS: thiobarbituric acid-reactive species; PC: protein carbonyl concentration; DS: damage score; PS: protection score; SD: standard deviation.