Table 2.
Correlation analyses for redox and clinical parameters.
| Redox/clinical parameters | Correlation coefficient (p level) | |||||
|---|---|---|---|---|---|---|
| TTO♦ | AO♦ | SARA score◊ | PR◊ | Sac. veloc.♦ | Sac. lat. | |
| SOD3 | −0.04 (0.811) | −0.04 (0.714) | 0.09 (0.428) | 0.10 (0.358) | −0.031 (0.824) | 0.15 (0.294) |
| CAT | −0.06 (0.751) | −0.07 (0.504) | 0.44 (<0.001) | 0.50 (<0.001) | -0.31 (0.025) | 0.31 (0.022) |
| CAT/SOD3 | 0.08 (0.650) | −0.06 (0.574) | 0.34 (0.002) | 0.38 (<0.001) | −0.21 (0.127) | 0.14 (0.303) |
| GST | −0.03 (0.885) | −0.09 (0.407) | 0.25 (0.017) | 0.21 (0.051) | 0.17 (0.221) | −0.16 (0.249) |
| R-SH | 0.28 (0.131) | −0.23 (0.027) | 0.07 (0.493) | 0.17 (0.112) | −0.26 (0.060) | 0.21 (0.122) |
| TBARS | −0.18 (0.347) | 0.07 (0.510) | −0.19 (0.083) | −0.16 (0.16) | −0.05 (0.742) | 0.06 (0.653) |
| PC | −0.43 (0.014) | 0.29 (0.013) | −0.20 (0.094) | −0.25 (0.033) | −0.04 (0.799) | 0.006 (0.971) |
| DS | −0.34 (0.058) | 0.18 (0.084) | −0.24 (0.025) | −0.22 (0.036) | −0.04 (0.782) | −0.02 (0.880) |
| PS | −0.05 (0.774) | −0.30 (0.004) | 0.35 (0.001) | 0.44 (<0.001) | −0.21 (0.134) | 0.25 (0.072) |
| OXY score | −0.29 (0.111) | 0.30 (0.005) | −0.38 (<0.001) | −0.41 (<0.001) | 0.09 (0.528) | −0.15 (0.261) |
SOD3: superoxide dismutase activity; CAT: catalase activity; GST: glutathione S-transferase activity; R-SH: reducing thiol total concentration; TBARS: thiobarbituric acid-reactive species; PC: protein carbonyl concentration; DS: damage score; PS: protection score; SD: standard deviation; TTO: time to onset (in presymptomatic individuals); AO: age at onset; PR: progression rate. ♦Corrected for repeat length; ◊corrected for disease duration and CAG repeat length.