Table 3.
Associations between different drugs and cancers among different age groups.
| Drug (ATCa code), cancer type, and age (years) | Adjusted odd ratio (95% CI) | Case patients, n | Control patients, n | |||||||||
|
|
|
Exposure | Nonexposure | Exposure | Nonexposure | |||||||
| Aspirin (B01AC06) |
|
|
|
|
|
|||||||
|
|
All |
|
|
|
|
|
||||||
|
|
|
≥65 | 0.954** (0.923-0.985) | 6964 | 23,485 | 28,665 | 93,131 | |||||
| 40-64 | 0.871*** (0.831-0.913) | 2825 | 37,679 | 12,925 | 149,091 | |||||||
| 20-39 | 1.000 (0.679-1.472) | 37 | 8255 | 136 | 33,032 | |||||||
| ≥20 | 0.924*** (0.900-0.949) | 9826 | 69,419 | 41,726 | 275,254 | |||||||
| Metformin (A10BA02) |
|
|
|
|
|
|||||||
|
|
Colorectal |
|
|
|
|
|
||||||
|
|
|
≥65 | 0.881* (0.794-0.979) | 797 | 4532 | 3231 | 18,085 | |||||
| 40-64 | 0.799*** (0.701-0.912) | 456 | 4757 | 2076 | 18,776 | |||||||
| 20-39 | 0.448 (0.148-1.358) | 4 | 776 | 28 | 3092 | |||||||
| ≥20 | 0.845*** (0.779-0.916) | 1257 | 10,065 | 5335 | 39,953 | |||||||
| Sitagliptin (A10BH01) |
|
|
|
|
|
|||||||
|
|
Pancreatic |
|
|
|
|
|
||||||
|
|
|
≥65 | 1.901* (1.125-3.213) | 28 | 632 | 50 | 2590 | |||||
| 40-64 | 2.303* (1.109-4.781) | 16 | 565 | 27 | 2297 | |||||||
| 20-39 | N/Ab | 0 | 91 | 0 | 364 | |||||||
| ≥20 | 1.981** (1.298-3.024) | 44 | 1288 | 77 | 5251 | |||||||
| Benzodiazepine derivatives (N05) |
|
|
|
|
|
|||||||
|
|
Brain |
|
|
|
|
|
||||||
|
|
|
≥65 | 1.090 (0.787-1.508) | 78 | 201 | 256 | 860 | |||||
| 40-64 | 1.456** (1.112-1.905) | 111 | 379 | 287 | 1673 | |||||||
| 20-39 | 2.409** (1.364-4.257) | 24 | 201 | 46 | 854 | |||||||
| ≥20 | 1.379** (1.138-1.670) | 213 | 781 | 589 | 3387 | |||||||
aATC: Anatomical Therapeutic Chemical.
bN/A: not applicable.
*P<.05.
**P<.01.
***P<.001.