Figure 2.

miRNA-92a-3p expression is upregulated in the plasma and callus of the fracture + TBI mouse model

(A) miRNA-92a-3p plasma expression. RT-PCR showed that on day 3, day 7, and day 14 after modeling, the relative expression level of plasma miRNA-92a-3p in the femoral Fracture+TBI group was significantly higher than that in other groups. (B) Micro-CT (mCT) scan reconstruction of femoral callus. On day 14 and day 21 after modeling, the callus in the Fracture+TBI group was more evident than that in the isolated Fracture group. (C–F) mCT measurements of femoral callus at day 14 and day 21 after fracture modeling. Bone mass density (BMD), tissue volume (TV), bone volume (BV), and percent bone volume (BV/TV) are displayed. n = 5; data are presented as mean ± SD (∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; # no significance).