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. 2021 Feb 15;23:1345–1359. doi: 10.1016/j.omtn.2021.02.008

Figure 6.

Figure 6

Local administration of miRNA-92a-3p accelerates femur fracture healing in mice

(A–C) mCT-produced 3D images of bone callus formation at the fracture site on day 21 after modeling, comparing the (A) agomiRNA-92a-3p group, (B) antagomiRNA-92a-3p group, and (C) control group healing (PBS). (D–F) H&E tissue section staining comparing the (D) agomiRNA-92a-3p group, I antagomiRNA-92a-3p group, and (F) control group fracture-end healing on day 21 after modeling. (G–J) Analysis of the mCT presenting the BV (G), TV (H), BV/TV (I), and BMD (J) of bone callus on day 21 after modeling. (K–N) qPCR analysis of Col1a1 (M), ALP (N), OCN (K), and Runx2 (L) expression in the control, agomiR-92a-3p, antagomirmiR-92a-3p group on day 21 after modeling. (O and P) Western blot analysis of Col1a1, ALP, OCN, and Runx2 levels in the control, agomiR-92a-3p, and antagomiR-92a-3p group on day 14 (O) and day 21 (P) after modeling. n = 5; data are presented as mean ± SD (∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; # no significance).