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. 2021 Jan 26;23:1334–1344. doi: 10.1016/j.omtn.2021.01.022

Figure 3.

Figure 3

miR-188-3p-enriched exosomes alleviated substantia nigra damage in MPTP-induced mice models

We constructed MPTP-induced mice models and injected them with miR-188-3p-enriched exosomes. (A) Mice pole test results. (B) Mice wire-hang test results. (C) Nissl staining results of mice in sham, MPTP, MPTP + normal exosomes, and MPTP + miR-188-3p-enriched exosome groups. (D) Quantitative analyses of Nissl staining results. (E) Immunohistochemistry results of TH in sham, MPTP, MPTP + normal exosomes, and MPTP + miR-188-3p-enriched exosome groups. (F) Quantitative analyses of immunohistochemistry results. (G) FISH results of miR-188-3p and TH in sham, MPTP, MPTP + normal exosomes, and MPTP + miR-188-3p-enriched exosome groups. (H) Immunofluorescence results of α-syn in sham, MPTP, MPTP + normal exosomes, and MPTP + miR-188-3p-enriched exosome groups. (I) Quantitative analyses of FISH intensity. (J) Quantitative analyses of immunofluorescence intensity. (K) RT-PCR results of miR-188-3p in sham, MPTP, MPTP + normal exosomes, and MPTP + miR-188-3p-enriched exosome groups in mice SNpc. Data are reported as mean ± SD, n = 8. ∗p < 0.1, ∗∗p < 0.01, ∗∗∗p < 0.001.