Figure 4.

The injection of miR-188-3p-enriched exosomes suppressed the levels of CDK5 and NLRP3 in MPTP-induced PD mice

(A) Western blot results of TH, α-syn, and p-α-syn in sham, MPTP, MPTP + normal exosomes, and MPTP + miR-188-3p-enriched exosome groups in mice SNpc. (B) Quantitative analyses of western blot results. (C) Western blot results of CDK5, LC3-I, LC3-II, and p62 in each group in mice SNpc. (D) Quantitative analyses of western blot results. (E) Western blot results of NLRP3, ASC, Casp1 p20, and Procasp1 in each group in mice SNpc. (F) Quantitative analyses of western blot results. (G) RT-PCR results of NLRP3 and CDK5 in each group. (H) The levels of IL-6 and TNF-α in serum from each group. (I) The levels of IL-1β and IL-18 in serum from each group. Data are reported as mean ± SD, n = 8. ∗p < 0.1, ∗∗p < 0.01, ∗∗∗p < 0.001.