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. 2020 Nov 11;24(1):106–116. doi: 10.4048/jbc.2021.24.e2

Table 1. Comprehensive paraneoplastic autoantibody and autoimmune epilepsy work-up.

Serum paraneoplastic autoantibodies CSF autoimmune epilepsy labs
Test Result (reference value) Test Result (reference value)
ANNA-1 (Hu) Negative (< 1:240 titer) NMDA-R AB CBA Negative (negative)
ANNA-2 (Ri) Negative (< 1:240 titer) VGKC Complex AB IPA 0 (≤ 0.02 nmol/L)
ANNA-3 Negative (< 1:240 titer) LGI1-IgG CBA Negative (negative)
AGNA-1 Negative (< 1:240 titer) CASPR2-IgG CBA Negative (negative)
PCA-1 (Yo) Negative (< 1:240 titer) GAD65 AB Assay 0 (≤ 0.02 nmol/L)
PCA-2 Negative (< 1:240 titer) GABA-B-R AB CBA Negative (negative)
PCA-Tr Negative (< 1:240 titer) AMPA-R AB CBA Negative (negative)
Amphiphysin AB Negative (< 1:240 titer) ANNA-1 Negative (< 1:2 titer)
CRMP-5-IgG Negative (< 1:240 titer) ANNA-2 Negative (< 1:2 titer)
P/Q CAL CHAN AB 0.01 (≤ 0.02 nmol/L) ANNA-3 Negative (< 1:2 titer)
N-CAL CHAN AB 0 (≤ 0.03 nmol/L) AGNA-1 Negative (< 1:2 titer)
ACHR GANG NEUR AB 0 (≤ 0.02 nmol/L) PCA-2 Negative (< 1:2 titer)
NEUR K CHAN AB 0 (≤ 0.02 nmol/L) PCA-Tr Negative (< 1:2 titer)
STRIATIONAL AB Negative (< 1:240 titer) Amphiphysin AB Negative (< 1:2 titer)
CRMP-5-IgG Negative (< 1:2 titer)

CSF = cerebrospinal fluid; ANNA = anti-neuronal nuclear antibody; AGNA = anti-glial nuclear antibody; PCA = Purkinje cell cytoplasmic antibody; AB = antibody; CRMP-5 = collapsin response-mediator protein-5; IgG = immunoglobulin G; P/Q CAL CHAN = P/Q-type calcium channel; N-CAL CHAN = N-type calcium channel; ACHR GANG NEUR = acetylcholine receptor ganglionic neuronal; NEUR K = neuronal potassium channel; NMDA-R = N-methyl-d-aspartate receptor; CBA = collagen-binding activity; VGKC Complex AB IPA = neuronal voltage-gated potassium channel antibody; LGI1 = leucine-rich gliomainactivated 1; CASPR2 = contactin-associated protein-like 2; GAD65= glutamic acid decarboxylase; GABA-B-R = gamma aminobutyric acid receptor type B; AMPA-R = AMPA receptor.