Table 1. Comprehensive paraneoplastic autoantibody and autoimmune epilepsy work-up.
Serum paraneoplastic autoantibodies | CSF autoimmune epilepsy labs | ||
---|---|---|---|
Test | Result (reference value) | Test | Result (reference value) |
ANNA-1 (Hu) | Negative (< 1:240 titer) | NMDA-R AB CBA | Negative (negative) |
ANNA-2 (Ri) | Negative (< 1:240 titer) | VGKC Complex AB IPA | 0 (≤ 0.02 nmol/L) |
ANNA-3 | Negative (< 1:240 titer) | LGI1-IgG CBA | Negative (negative) |
AGNA-1 | Negative (< 1:240 titer) | CASPR2-IgG CBA | Negative (negative) |
PCA-1 (Yo) | Negative (< 1:240 titer) | GAD65 AB Assay | 0 (≤ 0.02 nmol/L) |
PCA-2 | Negative (< 1:240 titer) | GABA-B-R AB CBA | Negative (negative) |
PCA-Tr | Negative (< 1:240 titer) | AMPA-R AB CBA | Negative (negative) |
Amphiphysin AB | Negative (< 1:240 titer) | ANNA-1 | Negative (< 1:2 titer) |
CRMP-5-IgG | Negative (< 1:240 titer) | ANNA-2 | Negative (< 1:2 titer) |
P/Q CAL CHAN AB | 0.01 (≤ 0.02 nmol/L) | ANNA-3 | Negative (< 1:2 titer) |
N-CAL CHAN AB | 0 (≤ 0.03 nmol/L) | AGNA-1 | Negative (< 1:2 titer) |
ACHR GANG NEUR AB | 0 (≤ 0.02 nmol/L) | PCA-2 | Negative (< 1:2 titer) |
NEUR K CHAN AB | 0 (≤ 0.02 nmol/L) | PCA-Tr | Negative (< 1:2 titer) |
STRIATIONAL AB | Negative (< 1:240 titer) | Amphiphysin AB | Negative (< 1:2 titer) |
CRMP-5-IgG | Negative (< 1:2 titer) |
CSF = cerebrospinal fluid; ANNA = anti-neuronal nuclear antibody; AGNA = anti-glial nuclear antibody; PCA = Purkinje cell cytoplasmic antibody; AB = antibody; CRMP-5 = collapsin response-mediator protein-5; IgG = immunoglobulin G; P/Q CAL CHAN = P/Q-type calcium channel; N-CAL CHAN = N-type calcium channel; ACHR GANG NEUR = acetylcholine receptor ganglionic neuronal; NEUR K = neuronal potassium channel; NMDA-R = N-methyl-d-aspartate receptor; CBA = collagen-binding activity; VGKC Complex AB IPA = neuronal voltage-gated potassium channel antibody; LGI1 = leucine-rich gliomainactivated 1; CASPR2 = contactin-associated protein-like 2; GAD65= glutamic acid decarboxylase; GABA-B-R = gamma aminobutyric acid receptor type B; AMPA-R = AMPA receptor.