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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: J Cell Physiol. 2020 Oct 20;236(5):3366–3382. doi: 10.1002/jcp.30109

Table 1:

Organs affected, and clinical pathology associated with SARS-CoV-2

Organ/System Symptoms Pathological changes/Lesions References
Respiratory tract Dry cough, sneezing, dyspnea,
Shortness of breath
Interstitial pneumonia with infiltration of immune cells, hypoxemia, metabolic acidosis (Li et al., 2020; Zhou et al., 2020)
Gastrointestinal tract Diarrhea Dehydration (Song et al., 2020)
Immune system Fewer, viral sepsis Lymph node atrophy, lymphopenia, cytokine storm (Tan et al., 2020)
Heart Rapid heart rate, fatigue, cardiac arrest Cardiac dilatation, heart failure, Myocardial infarcts (Libby, 2020)
Blood vessels Rashes on foot Microcirculation dysfunction,
Inflamed blood vessels
(Varga et al., 2020)
Kidney Blood in urine Acute kidney injury, focal hemorrhages (Batlle et al., 2020)
Liver Increased ALT and AST, liver enlargement, infiltration of immune cells (Zhang et al., 2020; Zhou et al., 2020)
Nervous system Loss of taste and smell, Dizziness, headache Edema and scattered degeneration (Xydakis et al., 2020)
Blood clotting system Increased blood clotting Coagulopathy, deep vein thrombosis, stroke, D-Dimer (Varga et al., 2020; Wang et al., 2020)