Skip to main content
. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Microcirculation. 2021 Jan 9;28(2):e12662. doi: 10.1111/micc.12662

Figure 3. Occlusion Index (OI) associates with clinical variables in subjects with homozygous SCD (HbSS).

Figure 3.

(A&B) A bimodal distribution of the kernel density of the OI among the subjects with homozygous SCD was identified. Subjects were categorized into two groups (Low OI group and High OI group) based on the local minimum of 2.18% as the cutoff threshold. Subjects with higher OIs displayed significantly lower hemoglobin levels (C), significantly higher serum lactate dehydrogenase levels (D) and absolute reticulocyte counts (E), and significantly lower fetal hemoglobin levels (F) and mean corpuscular volume (G), compared to those with lower OIs. Colored horizontal lines represent mean of data set. Statistical significance between groups defined by one-way ANOVA or Mann-Whitney U test depending on data normality (P < 0.05).