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. 2021 Feb 16;12:607691. doi: 10.3389/fimmu.2021.607691

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Copyright © 2021 Batterman, Cabrera, Moore and Rosene.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Greater proportion of T cells in the white matter parenchyma with age: (A,B) Representative region of interest images for CD3⁺ stained T cells in a young (A) and old (B) monkey. Inset shows detail, location of inset marked with * in large image. Scale bars are 100 μm. (C,D) The percentage of perivascular T cells decreases while the percentage in the parenchyma increases with age in the cingulum bundle; (E,F) The percentage of perivascular T cells as well as those in the parenchyma does not change with age in the corpus callosum. CB, cingulum bundle; CC, corpus callosum. N = 34.