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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Neurobiol Aging. 2020 Dec 29;100:72–82. doi: 10.1016/j.neurobiolaging.2020.12.019

Table 5.

Cortical clusters where the association between overall LC contrast and thickness was more positive in older than in younger adults (A) and positive in older adults (B)

Region Hemi-sphere Size (mm2) Peak vertex* CWP**
X Y Z
A. Overall LC - thickness association more positive in OA vs. YA
 Superior parietal Left 1377.59 −16.0 −89.4 21.9 0.0005
 Rostral middle frontal Left 1028.72 −35.5 31.4 14.8 0.0106
 Paracentral Left 953.99 −8.1 −22.4 65.1 0.0184
 Middle temporal Right 1447.35 51.1 −12.5 −20.7 0.0008
 Postcentral Right 1301.42 14.4 −33.8 64.5 0.0021
 Fusiform Right 1282.95 36.0 −43.5 −13.9 0.0023
 Lateral occipital Right 1230.74 48.2 −75.0 5.9 0.0032
 Paracentral Right 905.96 5.9 −12.1 52.7 0.0251
 Banks superior temporal sulcus Right 903.84 46.0 −42.9 13.9 0.0259
 Lateral occipital Right 811.95 23.9 −90.1 18.9 0.0475
B. Overall LC positively associated with thickness in OA
 Inferior parietal Left 5334.79 −44.4 −70.2 9.4 0.0001
 Pars triangularis Left 2829.49 −47.9 34.8 −8.5 0.0001
 Superior frontal Left 2590.56 −8.9 2.1 67.1 0.0001
 Inferior parietal Left 1350.49 −43.3 −63.9 38.9 0.0013
 Precentral Left 1039.94 −34.7 −21.0 49.8 0.0102
 Superior temporal Left 910.53 −59.4 −12.0 −3.3 0.0244
 Precentral Right 5682.29 40.8 −10.3 58.2 0.0001
 Precuneus Right 2556.13 6.7 −57.4 32.3 0.0001
 Inferior parietal Right 2260.05 37.0 −53.9 38.1 0.0001
 Lateral occipital Right 1783.10 40.8 −85.3 −13.0 0.0001
 Lingual Right 1602.38 20.4 −74.2 −8.8 0.0002
 Pars orbitalis Right 1389.28 45.8 30.2 −12.3 0.0006
 Bank superior temporal sulcus Right 1154.07 48.8 −40.6 12.5 0.0056
 Rostral middle frontal Right 1007.60 31.0 41.6 20.2 0.0138

Note. LC = locus coeruleus; OA = older adults; YA = younger adults. There were no clusters where overall LC contrast was associated with thickness in younger adults.

*

Talairach coordinates of vertex with peak CWP value.

**

Cluster-wise probability (CWP) resulting from cluster-wise Monte Carlo correction for multiple comparisons, reflecting the probability of the cluster appearing by chance. Only clusters with CWP<.05 are listed.