Table 5.
Region | Hemi-sphere | Size (mm2) | Peak vertex* | CWP** | ||
---|---|---|---|---|---|---|
X | Y | Z | ||||
A. Overall LC - thickness association more positive in OA vs. YA | ||||||
Superior parietal | Left | 1377.59 | −16.0 | −89.4 | 21.9 | 0.0005 |
Rostral middle frontal | Left | 1028.72 | −35.5 | 31.4 | 14.8 | 0.0106 |
Paracentral | Left | 953.99 | −8.1 | −22.4 | 65.1 | 0.0184 |
Middle temporal | Right | 1447.35 | 51.1 | −12.5 | −20.7 | 0.0008 |
Postcentral | Right | 1301.42 | 14.4 | −33.8 | 64.5 | 0.0021 |
Fusiform | Right | 1282.95 | 36.0 | −43.5 | −13.9 | 0.0023 |
Lateral occipital | Right | 1230.74 | 48.2 | −75.0 | 5.9 | 0.0032 |
Paracentral | Right | 905.96 | 5.9 | −12.1 | 52.7 | 0.0251 |
Banks superior temporal sulcus | Right | 903.84 | 46.0 | −42.9 | 13.9 | 0.0259 |
Lateral occipital | Right | 811.95 | 23.9 | −90.1 | 18.9 | 0.0475 |
B. Overall LC positively associated with thickness in OA | ||||||
Inferior parietal | Left | 5334.79 | −44.4 | −70.2 | 9.4 | 0.0001 |
Pars triangularis | Left | 2829.49 | −47.9 | 34.8 | −8.5 | 0.0001 |
Superior frontal | Left | 2590.56 | −8.9 | 2.1 | 67.1 | 0.0001 |
Inferior parietal | Left | 1350.49 | −43.3 | −63.9 | 38.9 | 0.0013 |
Precentral | Left | 1039.94 | −34.7 | −21.0 | 49.8 | 0.0102 |
Superior temporal | Left | 910.53 | −59.4 | −12.0 | −3.3 | 0.0244 |
Precentral | Right | 5682.29 | 40.8 | −10.3 | 58.2 | 0.0001 |
Precuneus | Right | 2556.13 | 6.7 | −57.4 | 32.3 | 0.0001 |
Inferior parietal | Right | 2260.05 | 37.0 | −53.9 | 38.1 | 0.0001 |
Lateral occipital | Right | 1783.10 | 40.8 | −85.3 | −13.0 | 0.0001 |
Lingual | Right | 1602.38 | 20.4 | −74.2 | −8.8 | 0.0002 |
Pars orbitalis | Right | 1389.28 | 45.8 | 30.2 | −12.3 | 0.0006 |
Bank superior temporal sulcus | Right | 1154.07 | 48.8 | −40.6 | 12.5 | 0.0056 |
Rostral middle frontal | Right | 1007.60 | 31.0 | 41.6 | 20.2 | 0.0138 |
Note. LC = locus coeruleus; OA = older adults; YA = younger adults. There were no clusters where overall LC contrast was associated with thickness in younger adults.
Talairach coordinates of vertex with peak CWP value.
Cluster-wise probability (CWP) resulting from cluster-wise Monte Carlo correction for multiple comparisons, reflecting the probability of the cluster appearing by chance. Only clusters with CWP<.05 are listed.