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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Neurobiol Aging. 2020 Dec 29;100:72–82. doi: 10.1016/j.neurobiolaging.2020.12.019

Table 6.

Cortical clusters where the association between rostral LC contrast and thickness was more positive in older than in younger adults (A) and positive in older adults (B) and where the association between caudal LC contrast and thickness was more positive in older than in younger adults (C) and negative in older adults (D) and younger adults (E)

Region Hemi-sphere Association with thickness Size (mm2) Peak vertex* CWP
X Y Z
A. Rostral LC contrast - thickness association more positive in OA vs. YA
 Superior parietal Left OA > YA 842.14 −22.9 −74.4 29.9 0.0387
B. Rostral LC contrast associated with thickness in OA
 Pars triangularis Left Positive 2633.77 −48.1 35.4 −6.3 0.0001
 Caudal middle frontal Left Positive 2288.88 −39.6 11.4 51.4 0.0001
 Superior frontal Left Positive 1958.83 −10.1 39.7 47.9 0.0001
 Superior parietal Left Positive 1811.48 −10.2 −87.1 29.1 0.0001
 Postcentral Left Positive 1472.10 −47.0 −25.4 33.9 0.0002
 Precuneus Left Positive 1391.17 −8.2 −45.3 44.3 0.0005
 Inferior parietal Left Positive 1091.19 −43.3 −64.6 40.3 0.0070
 Precentral Left Positive 974.53 −45.2 −10.9 39.7 0.0166
 Precentral Right Positive 4717.72 41.0 −9.8 58.5 0.0001
 Supramarginal Right Positive 3809.56 57.9 −39.9 35.6 0.0001
 Lateral occipital Right Positive 2799.21 47.8 −77.2 5.1 0.0001
 Isthmus cingulate Right Positive 2070.17 8.9 −53.3 9.6 0.0001
 Rostral middle frontal Right Positive 1424.36 42.7 33.6 28.2 0.0002
 Superior frontal Right Positive 1338.58 6.8 40.8 46.9 0.0008
 Pars triangularis Right Positive 1096.91 54.2 26.6 8.1 0.0047
C. Caudal LC contrast - thickness association more positive in OA vs. YA
 Superior parietal Left OA > YA 3135.14 −19.1 −86.0 18.8 0.0001
 Supramarginal Right OA > YA 1278.17 45.1 −28.6 37.7 0.0014
 Superior parietal Right OA > YA 928.04 25.8 −79.4 21.4 0.0227
 Paracentral Right OA > YA 841.08 15.6 −38.4 53.3 0.0409
D. Caudal LC contrast associated with thickness in OA
 Rostral middle frontal Left Negative 857.23 −19.1 57.7 −11.9 0.0351
E. Caudal LC contrast associated with thickness in YA
 Lateral occipital Left Negative 2959.26 −34.0 −87.6 9.6 0.0001
 Paracentral Left Negative 1075.54 −5.4 −18.8 52.4 0.0065
 Superior parietal Right Negative 2419.58 20.6 −41.3 58.2 0.0001

Note. LC = locus coeruleus; OA = older adults; YA = younger adults. There were no clusters in younger adults where rostral LC contrast was associated with thickness.

*

Talairach coordinates of vertex with peak CWP value.

**

Cluster-wise probability (CWP) resulting from cluster-wise Monte Carlo correction for multiple comparisons, reflecting the probability of the cluster appearing by chance. Only clusters with CWP<.05 are listed.