Table 6.
Region | Hemi-sphere | Association with thickness | Size (mm2) | Peak vertex* | CWP | ||
---|---|---|---|---|---|---|---|
X | Y | Z | |||||
A. Rostral LC contrast - thickness association more positive in OA vs. YA | |||||||
Superior parietal | Left | OA > YA | 842.14 | −22.9 | −74.4 | 29.9 | 0.0387 |
B. Rostral LC contrast associated with thickness in OA | |||||||
Pars triangularis | Left | Positive | 2633.77 | −48.1 | 35.4 | −6.3 | 0.0001 |
Caudal middle frontal | Left | Positive | 2288.88 | −39.6 | 11.4 | 51.4 | 0.0001 |
Superior frontal | Left | Positive | 1958.83 | −10.1 | 39.7 | 47.9 | 0.0001 |
Superior parietal | Left | Positive | 1811.48 | −10.2 | −87.1 | 29.1 | 0.0001 |
Postcentral | Left | Positive | 1472.10 | −47.0 | −25.4 | 33.9 | 0.0002 |
Precuneus | Left | Positive | 1391.17 | −8.2 | −45.3 | 44.3 | 0.0005 |
Inferior parietal | Left | Positive | 1091.19 | −43.3 | −64.6 | 40.3 | 0.0070 |
Precentral | Left | Positive | 974.53 | −45.2 | −10.9 | 39.7 | 0.0166 |
Precentral | Right | Positive | 4717.72 | 41.0 | −9.8 | 58.5 | 0.0001 |
Supramarginal | Right | Positive | 3809.56 | 57.9 | −39.9 | 35.6 | 0.0001 |
Lateral occipital | Right | Positive | 2799.21 | 47.8 | −77.2 | 5.1 | 0.0001 |
Isthmus cingulate | Right | Positive | 2070.17 | 8.9 | −53.3 | 9.6 | 0.0001 |
Rostral middle frontal | Right | Positive | 1424.36 | 42.7 | 33.6 | 28.2 | 0.0002 |
Superior frontal | Right | Positive | 1338.58 | 6.8 | 40.8 | 46.9 | 0.0008 |
Pars triangularis | Right | Positive | 1096.91 | 54.2 | 26.6 | 8.1 | 0.0047 |
C. Caudal LC contrast - thickness association more positive in OA vs. YA | |||||||
Superior parietal | Left | OA > YA | 3135.14 | −19.1 | −86.0 | 18.8 | 0.0001 |
Supramarginal | Right | OA > YA | 1278.17 | 45.1 | −28.6 | 37.7 | 0.0014 |
Superior parietal | Right | OA > YA | 928.04 | 25.8 | −79.4 | 21.4 | 0.0227 |
Paracentral | Right | OA > YA | 841.08 | 15.6 | −38.4 | 53.3 | 0.0409 |
D. Caudal LC contrast associated with thickness in OA | |||||||
Rostral middle frontal | Left | Negative | 857.23 | −19.1 | 57.7 | −11.9 | 0.0351 |
E. Caudal LC contrast associated with thickness in YA | |||||||
Lateral occipital | Left | Negative | 2959.26 | −34.0 | −87.6 | 9.6 | 0.0001 |
Paracentral | Left | Negative | 1075.54 | −5.4 | −18.8 | 52.4 | 0.0065 |
Superior parietal | Right | Negative | 2419.58 | 20.6 | −41.3 | 58.2 | 0.0001 |
Note. LC = locus coeruleus; OA = older adults; YA = younger adults. There were no clusters in younger adults where rostral LC contrast was associated with thickness.
Talairach coordinates of vertex with peak CWP value.
Cluster-wise probability (CWP) resulting from cluster-wise Monte Carlo correction for multiple comparisons, reflecting the probability of the cluster appearing by chance. Only clusters with CWP<.05 are listed.